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Medically reviewed by Alan Carter, Pharm. How it works Forms and strengths Time in system Factors that affect duration Safety Bottom line Tramadol is a prescription opioid used to treat moderate to severe pain. Read on to find out how this medication works and how long it typically stays in your system. How does it work? Does it come in different forms and strengths? How long does it stay in your system? What can affect how long it stays in your body? Safety issues.
The bottom line. Read this next. How to Recognize and Treat Tramadol Addiction. Medically reviewed by Timothy J. Legg, Ph. When tramadol is inside a body compartment, the body must decide what it wants to do with the drug. The enzyme CYP3D6 breaks down tramadol into the potent desmethyltramadol. The rest either remains as the native form of tramadol both tramadol and desmethyltramadol are free to act on mu-opioid or nerve cell receptors or is slowly filtered by the kidneys, from the blood into the urine, where it is excreted from the body.
This is known as clearance. A small percentage of tramadol is filtered by the digestive tract into feces for excretion. Hope is Just a Phone Call Away Tramadol Detection Once in the urine, tramadol can be detected by specialized urine drug screens. Treatment for Tramadol Addiction If you think you may have a tramadol addiction or are struggling with tramadol abuse, seek professional help as soon as possible.
Find Hope Today. Further Reading. Related Blogs. October 18, Learn More. Get Help Now. We're here to help. Call us today. The only way to get tramadol out of your system is to stop taking the drug and allow your body time to process and eliminate it. If you suspect an overdose of tramadol, administering Narcan naloxone , often available at local health departments as a nasal spray, will inhibit the dangerous effects of too much tramadol on the respiratory system, though it will not speed up the elimination of the tramadol.
Keep this in mind as it may be necessary to administer additional doses of naloxone if enough tramadol remains in the body. To prevent an overdose of tramadol, you must only take the amount prescribed as prescribed on the schedule prescribed. It is dangerous to crush or cut extended relief tablets or capsules as doing so will release a larger dose all at once.
Symptoms of a tramadol overdose can include:. Tramadol interacts with many other medications, which can lead to life-threatening health concerns including breathing problems, sedation, and coma.
Of special concern are interactions with benzodiazepines , monoamine oxidase inhibitors MAOIs , and alcohol. Discuss all medications you take, plan to take, or plan to stop taking with your doctor so these can be screened and adjusted to prevent a dangerous interaction.
Do not drink alcohol, take medication containing alcohol, or use street drugs while taking tramadol or you risk a serious, possibly life-threatening interaction. As with the case of all opioid drugs, tramadol overdoses can be treated with Narcan naloxone if they are detected early enough. If you think someone has overdosed, call immediately, administer naloxone, and begin CPR if possible.
If you stop using it suddenly, you may experience withdrawal symptoms such as anxiety, muscle aches and pain, excessive sweating, and insomnia. Tramadol withdrawal can begin one to two days after the last dose, peak after day three, and subside within one to two weeks.
Your doctor will give a discontinuation schedule when its time to stop using tramadol to avoid these symptoms. Tramadol carries a high risk of dependence, even when taken as prescribed. Treatment options for opiate use disorder include:. When transitioning off of opioids like tramadol, your doctor may prescribe other medications to ease withdrawal symptoms and prevent breakthrough pain.
For more mental health resources, see our National Helpline Database. Learn the best ways to manage stress and negativity in your life. Ultram CIV tramadol hydrochloride tablets. False-positive urine phencyclidine immunoassay screen result caused by interference by tramadol and its metabolites.
Tramadol is a generic opioid medication that is also sold under the brand names Conzip and Ultram. It is often prescribed for pain after surgery or for some chronic pain conditions. However, like other opioids, tramadol can be habit-forming and lead to physical dependence. If you have been abusing tramadol and you are about to detox or you need to pass a drug test, you may be wondering how long tramadol stays in your system.
Well, there are numerous different factors that dictate how long drugs are in your system and for how long they will show up on a drug test. Tramadol is weaker than, but comparable to, other prescription opioids like morphine and codeine. The drug binds to opioid receptors in the brain and blocks pain signals to reduce feelings of pain. In the process, the drug increases the reuptake of norepinephrine and serotonin in the brain.
These chemicals affect the reward system and are what make opioids so addictive.
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