A review of 16 studies in people with high blood pressure or an elevated risk of it found that taking —2, mg of GSE daily significantly reduced systolic and diastolic blood pressure the top and bottom number by an average of 6.
The most promising results came from lower doses of — mg daily for 8—16 weeks, rather than a single dose of mg or more 4. Another study in 29 adults with high blood pressure found that taking mg of GSE daily lowered systolic blood pressure by 5. Some studies suggest that GSE may improve blood flow.
In an 8-week study in 17 healthy postmenopausal women, taking mg of GSE had blood-thinning effects, potentially reducing the risk of blood clots 6.
An additional study in 8 healthy young women assessed the effects of a single mg dose of proanthocyanidin from GSE immediately followed by 6 hours of sitting. An elevated blood level of LDL bad cholesterol is a known risk factor for heart disease.
The oxidation of LDL cholesterol significantly increases this risk and plays a central role in atherosclerosis, or the buildup of fatty plaque in your arteries 8. GSE supplements have been found to reduce LDL oxidation triggered by high fat diets in several animal studies 9 , 10 , Some research in humans shows similar results 12 , In another study, 61 healthy adults saw a However, a similar study was unable to replicate these results 5 , Additionally, a study in 87 people undergoing heart surgery found that taking mg of GSE the day before surgery significantly reduced oxidative stress.
Therefore, GSE likely protected against further heart damage Increasing flavonoid consumption may improve collagen synthesis and bone formation. In fact, animal studies have found that adding GSE to either a low calcium, standard, or high calcium diet can increase bone density, mineral content, and bone strength 16 , Rheumatoid arthritis is an autoimmune condition that results in severe inflammation and the destruction of bone and joints. Animal studies have shown that GSE may suppress bone destruction in inflammatory autoimmune arthritis 18 , 19 , GSE also significantly reduced pain, bony spurs, and joint damage in osteoarthritic mice, improving collagen levels and reducing cartilage loss One of the components of GSE is gallic acid, which animal and lab studies have shown can inhibit the formation of fibrils by beta-amyloid peptides Animal studies have found that GSE may prevent memory loss, improve cognitive status and brain antioxidant levels, and reduce brain lesions and amyloid clusters 24 , 25 , 26 , One week study in healthy older adults found that taking mg of GSE daily improved attention, language, and both immediate and delayed memory However, human studies on the use of GSE in adults with preexisting memory or cognitive deficits are lacking.
Animal studies have shown that GSE may reduce kidney damage and improve function by reducing oxidative stress and inflammatory damage 29 , 30 , In one study, 23 people diagnosed with chronic renal failure were given 2 grams of GSE daily for 6 months and then compared with a placebo group. This means that the kidneys of those in the test group were much better able to filter urine than the kidneys of those in the placebo group Studies have shown that GSE inhibits the growth of common foodborne bacteria, including Campylobacter and E.
In lab studies, GSE has been found to inhibit 43 strains of antibiotic-resistant Staphylococcus aureus bacteria Candida is a common yeast-like fungus that can sometimes result in candida overgrowth , or thrush. GSE is widely used in traditional medicine as a remedy for candida. Another study found that people who took grape seed extract after experiencing a sports injury had less swelling than those who took placebo. There is not enough evidence to say whether taking grape seed extract can lower cholesterol, although preliminary studies show promising results.
A study of 40 people with high cholesterol looked at whether taking grape seed extract, chromium, a combination of both, or placebo for 2 months would lower cholesterol. The combination of grape seed extract and chromium was more effective than either grape seed alone or placebo in lowering total and LDL cholesterol.
Another study looked at the effects of a proprietary grape seed extract on lipid peroxidation the breakdown of fats in the blood in a group of heavy smokers. In the study, 24 healthy male smokers aged 50 years or older took either placebo or 2 capsules 75 mg of a grape procyanidin extracts and soy phosphatidalcholine , twice daily for 4 weeks. LDL cholesterol levels were lower in those taking the grape seed supplement than those taking placebo.
Theoretically, grape seed extract might help treat hypertension or high blood pressure. Antioxidants, like the ones found in grape seed, help protect blood vessels from damage. Damaged blood vessels can lead to higher blood pressure. In several animal studies, grape seed extract substantially reduced blood pressure. More research is needed to determine whether grape seed extract helps people with high blood pressure. Studies have found that grape seed extracts may prevent the growth of breast, stomach, colon, prostate, and lung cancer cells in test tubes.
However, there is no clear evidence whether it works in humans. Antioxidants, such as those found in grape seed extract, may help reduce the risk of developing cancer.
Grape seed extract may also help prevent damage to human liver cells caused by chemotherapy medications. Talk to your doctor or pharmacist before combining antioxidants with any chemotherapy drugs to make sure they interact safely together, and that they do not interfere with effects of the chemotherapy medications. Grape seed is available as a dietary supplement in capsules, tablets, and liquid extracts.
Pediatric Grape seed extracts are not recommended for children. Grapes, however, make a healthy and safe snack for children. Grape seed often comes in standardized extracts with certain levels of proanthocyanidins.
Speak to a knowledgeable provider to find the right dose for your issue. The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and interact with other herbs, supplements, or medications.
For these reasons, you should take herbs with care, under the supervision of a health care provider qualified in the field of botanical medicine. Common side effects include nausea, itching, dizziness, stomach upset, diarrhea, headache, sore throat, cough, and rash. Grape seed extract can potentially affect medications broken down by the liver.
Numerous medications are broken down by the liver, so check with your physician. Also, OPCs in grape seed extract may interact with the following:. Anticoagulants blood thinners : Grape seed extract may act as a blood thinner, and could increase the risk of bleeding if taken with other blood thinners such as warfarin Coumadin , clopidogrel Plavix , or aspirin.
If you are taking blood-thinning medications, or have bleeding disorders, ask your doctor before taking grape seed extract. Phenacetin: Drinking grape juice may increase how quickly the body breaks down Phenacetin to get rid of it.
This may decrease the effectiveness of the Phenacetin you are taking. Al-Habib A. J Toxicol Sci. Antilisterial activities of polyphenol-rich extracts of grapes and vinification byproducts.
J Agric Food Chem. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat Res. Banerjee B, Bagchi D. Beneficial effects of a novel IH grape seed proanthocyanidin extract in the treatment of chronic pancreatitis. Belleville J. The French paradox: possible involvement of ethanol in the protective effect against cardiovascular diseases.
Bernstein BJ, Grasso T. Prevalence of complementary and alternative medicine use in cancer patients. Bielory L. Complementary and alternative interventions in asthma, allergy, and immunology. Ann Allergy Asthma Immunol. Double-blind, placebo-controlled, randomised phase II trial of IH grape seed proanthocyanidin extract GSPE in patients with radiation-induced breast induration.
Radiother Oncol. In vivo antioxidant activity of procyanidin-rich extracts from grape seed and pine Pinus maritima bark in rats.
This label will give you information about the amount of active ingredient contained in each serving as well as information about other added ingredients. Note that in the United States and some other countries, dietary supplements are largely unregulated and supplements are not tested for safety.
As a result, the content of some products may differ from what is specified on the product label. If you choose to use this supplement, look for a product with a seal of approval from a third-party organization that provides quality testing, such as U.
Pharmacopeia, ConsumerLab. Also keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has often not been established.
Will eating grapes give me the same benefits of grape seed extract? Grapes can be a very healthy snack, but the concentration of the antioxidant OPC will be much higher in the extract than it will be when you consume a single serving of grapes.
What kind of grapes are best for my health? Any kind of grape—just like every whole fruit—provides certain nutritional benefits. The grapes that are most often studied regarding the health benefits mentioned above are red wine grapes. These grapes are sometimes, but not always, available in grocery stores. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life.
Grape Seed. Penn State Hershey. Milton S. Hershey Medical Center. Health Information Library. Natural Medicines Database. Professional Monograph. Memorial Sloan Kettering Cancer Center. About Herbs, Botanicals, and Other Products. March 30, Your Privacy Rights.
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